Doctor’s Best Time-release Niacin with niaXtend** provides niacin in an 8-hour extended-release form that may help avoid the uncomfortable skin flushing that commonly accompanies other forms of niacin.* Approximately 200 coenzymes contain niacin that play pivotal roles in metabolism and energy production within the body.
Additionally, research suggests that niacin, in combination with a well balanced diet, may help maintain healthy cholesterol levels that are already within the normal range.
Supports cardiovascular health
Extensive clinical research has shown that niacin as nicotinic acid may promote a favorable balance of blood lipids. The form of niacin typically found in multivitamins and fortified foods is “nicotinamide,” which exhibits vitamin B3 activity but not (the word “necessarily” has been removed) the cardiovascular benefits seen in research that examined nicotinic acid. According to a report endorsed by the American Heart Association, nicotinic acid appears capable of modulating blood lipids in part by altering their synthesis and inhibiting the mobilization of free fatty acids.1 Two niacin receptors, HM74 & HM74A, were recently discovered in humans. The HM74A receptors on adipose (fat) cells are believed to be particularly responsible for the helpful blood lipid-altering ability of nicotinic acid.2
Extended-release formula decreases chance of “Skin Flushing
Sustained-release Niacin with niaXtend provides an 8-hour extended-release tablet that enables more people to access the health-supportive aspects of niacin with less chance of experiencing the uncomfortable skin flushing that commonly accompanies (“the unspecialized niacin in” has been removed) immediate-release (IR) forms of the vitamin. Release of the eicosanoid prostaglandin D2 from skin cells is believed to be behind the skin flushing that may occur with niacin use. This “prickly heat” phenomenon results in a sensation of warmth, reddening, and/or tingling anywhere from 15 to 120 minutes after consumption of a large dose, often felt on the head, neck, and shoulders for up to an hour.